REGULATION OF HUMAN DECIDUAL CELL MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA (MIP-1-ALPHA) PRODUCTION BY INFLAMMATORY CYTOKINES

被引:41
作者
DUDLEY, DJ [1 ]
SPENCER, S [1 ]
EDWIN, S [1 ]
MITCHELL, MD [1 ]
机构
[1] UNIV AUCKLAND,DEPT PHARMACOL & CLIN PHARMACOL,AUCKLAND,NEW ZEALAND
来源
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1995年 / 34卷 / 04期
关键词
DECIDUAL CELLS; MIP-1-ALPHA; PRETERM LABOR; CHEMOKINES;
D O I
10.1111/j.1600-0897.1995.tb00946.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
PROBLEM: Inflammation of human gestational tissues is a key pathophysiologic event in the genesis of infection-associated preterm labor. Human gestational tissues produce several inflammatory cytokines after stimulation with bacterial products. These include interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha), and IL-6. Another class of cytokines includes chemokines of the ''C-C'' subclassification such as macrophage inflammatory protein-1 alpha (MIP-1 alpha). The purpose of this study was to determine whether cultured human decidual cells produce MIP-la: in response to other inflammatory cytokines. METHODS: Various concentrations of IL-1 beta, TNF alpha, IL-6, and IL-4 were incubated with confluent monolayer cultures of decidual cells isolated from normal term placentae for 16 h at 37 degrees C, and MIP-1 alpha concentrations in culture supernatants were measured by ELISA. RESULTS: We found that incubation of decidual cells with IL-1 beta, TNF alpha, and IL-4 resulted in significant concentration-dependent increases in MIP-1 alpha production. IL-6 had no effect on MIP-1 alpha production. CONCLUSIONS: Our data are the first to show that human decidual cells in culture produce MIP-1 alpha in response to other inflammatory cytokines. We suggest that decidual cell production of MIP-1 alpha is an important early event in the pathophysiology of infection-associated preterm labor.
引用
收藏
页码:231 / 235
页数:5
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