Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart

被引:63
作者
Freed, DH
Cunnington, RH
Dangerfield, AL
Sutton, JS
Dixon, IMC
机构
[1] St Boniface Gen Hosp, Res Ctr, Inst Cardiovasc Sci, Winnipeg, MB R2H 2A6, Canada
[2] Univ Manitoba, Dept Physiol, Winnipeg, MB R2H 2A6, Canada
基金
加拿大健康研究院;
关键词
cardiotrophin-1; wound healing; fibroblasts; heart failure; cardiac fibrosis;
D O I
10.1016/j.cardiores.2004.11.026
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ischemic heart disease is the most common cause of mortality worldwide. Cardiac fibroblasts and myofibroblasts, i.e., the hypersecretory, muscular, and contractile fibroblastic phenotype variant, play an important role in myocardial healing and are responsible for accumulation of collagen in the infarct scar as well as in viable myocardium. Thus, cardiac fibroblasts and myofibroblasts directly contribute to cardiac stiffness, altered performance, and ultimately to the onset of systolic and diastolic heart failure. Cardiotrophin-1 (CT-1) is a member of the IL-6 superfamily and is elevated in the serum of patients with ischemic heart disease and valvular heart disease; it is also known to induce cardiomyocyte hypertrophy in vitro. The recent, burgeoning awareness of the functions of IL-6 superfamily of cytokines within cardiovascular diseases predicates this summary of CT-1's effect in cardiac wound healing, and particularly after the induction of myocardial infarction. Further, we summarize recent results of cardiac CT-1 expression post-myocardial infarction (post-M1) as well as the effect of CT-1 on cultured primary adult rat cardiac fibroblasts with respect to proliferation and collagen secretion. It would appear that CT-1 plays an important and heretofore largely unrecognized role in infarct scar formation and angiogenesis in the rat model of chronic M1. Further work is required to determine factors that induce CT-1 expression, its interplay with other mediators of cardiac infarct wound healing in the setting of acute cardiac ischemia and chronic post-M1 heart failure, and ultimately whether it confers a beneficial effect or contributes to maladaptive cardiac fibrosis. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:782 / 792
页数:11
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