Anti-inflammatory properties of α- and γ-tocopherol

被引：224

作者：

Reiter, Elke ^{[1
]}

Jiang, Qing ^{[1
]}

Christen, Stephan ^{[1
]}

机构：

[1] Univ Bern, Inst Infect Dis, CH-3010 Bern, Switzerland

来源：

MOLECULAR ASPECTS OF MEDICINE | 2007年 / 28卷 / 5-6期

关键词：

vitamin E; inflammation; redox signaling; protein kinase c; nuclear factor kappa B; cyclooxygenase;

D O I：

10.1016/j.mam.2007.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha, beta, gamma, delta) that all have antioxidant activity. However,. recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, we discuss the anti-inflammatory properties of the two major forms of vitamin E, alpha-tocopherol (alpha T) and gamma-tocopherol (gamma T), and discuss the potential molecular mechanisms involved in these effects. While both tocopherols exhibit anti-inflammatory activity in vitro and in vivo, supplementation with mixed (gamma T-enriched) tocopherols seems to be more potent than supplementation with alpha T alone. This may explain the mostly negative out-comes of the recent large-scale interventional chronic disease prevention trials with alpha T only and thus warrants further investigation. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：668 / 691

页数：24

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