From G0 to S phase: A view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway

被引：122

作者：

Sun, Ang

Bagella, Luigi

Tutton, Steven

Romano, Gaetano

Giordano, Antonio

机构：

[1] Temple Univ, Sbarro Inst Canc Res & Mol Med, Coll Sci & Technol, Ctr Biotechnol, Philadelphia, PA 19122 USA

[2] Univ Sassari, Div Biochem & Biophys, Dept Biomed Sci, Natl Inst Biostruct & Biosyst, I-07100 Sassari, Italy

[3] Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, Italy

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2007年 / 102卷 / 06期

关键词：

tumor suppressor genes; Rb family; pRb2/p130; E2F; cell cycle; gene expression;

D O I：

10.1002/jcb.21609

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription factor E2F play an essential role in regulating cell cycle and, consequently, cell proliferation. This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression. J. Cell. Biochem. 102: 1400-1404, 2007. (c) 2007 Wiley-Liss, Inc.

引用

页码：1400 / 1404

页数：5