Autoimmunity in Chagas heart disease

被引：61

作者：

Leon, JS

Engman, DM ^{[1
]}

机构：

[1] Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Ctr, Dept Pathol, Chicago, IL 60611 USA

[2] Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Ctr, Dept Microbiol Immunol, Chicago, IL 60611 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2001年 / 31卷 / 5-6期

关键词：

myocarditis; Chagas heart disease myosin; autoimmunity;

D O I：

10.1016/S0020-7519(01)00163-1

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The possibility that cardiac autoimmunity contributes to the pathogenesis of Chagas heart disease is controversial. Ln this paper, we address the following questions regarding the genesis of autoimmunity in Chagas heart disease: (i) What mechanism(s) are potentially responsible for the generation of self-directed antibodies End lymphocytes? () What is the evidence that any of these mechanisms actually can occur? (iii) What are the implications of the presence of autoimmunity for other mechanisms of cardiac inflammation? (C) 2001 Published by Elsevier Science Ltd. on behalf of Australian Society for Parasitology Inc.

引用

页码：555 / 561

页数：7

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