Bulk and surface modifications of polylactide

被引：229

作者：

Wang, SG ^{[1
]}

Cui, WJ ^{[1
]}

Bei, JZ ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2005年 / 381卷 / 03期

关键词：

polylactide; bulk modification; surface modification; hydrophilicity; cell affinity; tissue engineering;

D O I：

10.1007/s00216-004-2771-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

This article reviews various methods of modifying the bulk and surface properties of poly(lactic acid) (PLA) so that the polymer may be used as a drug carrier in a drug delivery system (DDS) and as a cell scaffold in tissue engineering. Copolymerization of lactide with other lactone-type monomers or monomers with functional groups such as malic acid, copolymerization of lactide with macromolecular monomer such as poly(ethylene glycol) (PEG) or dextran, as well as blending polylactide and natural derivatives and other methods of bulk modification are discussed. Surface modifications of PLA-type copolymers, such as surface coating, chemical modification, and plasma treatment are described. Cell culture technology proves the efficiency of bulk and surface modification and the potential application of PLA in tissue engineering.

引用

页码：547 / 556

页数：10

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