Synthesis and properties of star-shaped polylactide attached to poly(amidoamine) dendrimer

被引：137

作者：

Cai, Q ^{[1
]}

Zhao, YL ^{[1
]}

Bei, JZ ^{[1
]}

Xi, F ^{[1
]}

Wang, SG ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, SKLPPC, Beijing 100080, Peoples R China

来源：

BIOMACROMOLECULES | 2003年 / 4卷 / 03期

关键词：

D O I：

10.1021/bm034051a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Star-shaped polylactide was synthesized by bulk polymerization of lactide with poly(amidoamine) (PAMAM) dendrimer as initiator, which was marked as PAMAM-g-PLA for simplicity. The nonlinear architecture of PAMAM-g-PLA was confirmed by gel permeation chromatograph, nuclear magnetic resonance, and differential scanning calorimetry analysis. Unlike the linear polylactide (PLA) with similar molecular weight, PAMAM-g-PLA had a higher hydrophilicity and a faster degradation rate because of shortened polymer chains and increased polar terminal endgroups due to its branch structure. The highly branched structure significantly accelerated the release of water-soluble bovine serum albumin from PAMAM-g-PLA microspheres, whereas the linear PLA with similar molecular weight exhibited an initial time lag release. This star polymer may have potential applications for hydrophilic drug delivery in tissue engineering, including growth factor and antibodies to induce tissue regeneration, by adjusting the chain lengths of PLA branches.

引用

页码：828 / 834

页数：7

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