Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria

被引：103

作者：

Andrianasolo, EH

Gross, H

Goeger, D

Musafija-Girt, M

McPhail, KP

Leal, RM

Mooberry, SL

Gerwick, WH ^{[1
]}

机构：

[1] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

[2] SW Fdn Biomed Res, San Antonio, TX 78245 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 07期

关键词：

D O I：

10.1021/ol050188x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.

引用

收藏

页码：1375 / 1378

页数：4

相关论文

共 24 条

[1] Research achievement award-D. John Faulkner [J].

Andersen, RJ ;

Ireland, CM ;

Molinski, TF ;

Bewley, CA .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (08) :1239-1251

[2] Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts [J].

Bewley, CA ;

Holland, ND ;

Faulkner, DJ .

EXPERIENTIA, 1996, 52 (07) :716-722

[3]

Bewley CA, 1998, ANGEW CHEM INT EDIT, V37, P2163, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2162::AID-ANIE2162>3.0.CO

[4]

2-2

[5] SWINHOLIDE-A IS A MICROFILAMENT DISRUPTING MARINE TOXIN THAT STABILIZES ACTIN DIMERS AND SEVERS ACTIN-FILAMENTS [J].

BUBB, MR ;

SPECTOR, I ;

BERSHADSKY, AD ;

KORN, ED .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (08) :3463-3466

[6] TOLYTOXIN AND NEW SCYTOPHYCINS FROM 3 SPECIES OF SCYTONEMA [J].

CARMELI, S ;

MOORE, RE ;

PATTERSON, GML .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (06) :1533-1542

[7] STRUCTURE OF SWINHOLIDE-A, A NEW MACROLIDE FROM THE MARINE SPONGE THEONELLA-SWINHOEI [J].

CARMELY, S ;

KASHMAN, Y .

TETRAHEDRON LETTERS, 1985, 26 (04) :511-514

[8]

DOI M, 1991, J ORG CHEM, V56, P3629, DOI 10.1021/jo00011a033

[9] Isolation of calyculins, calyculinamides, and swinholide H from the New Zealand deep-water marine sponge Lamellomorpha strongylata [J].

Dumdei, EJ ;

Blunt, JW ;

Munro, MHG ;

Pannell, LK .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (08) :2636-2639

[10]

FLATT PM, 2005, IN PRESS MARINE BIOL