Dielectric spectroscopy for bioanalysis: From 40 Hz to 26.5 GHz in a microfabricated wave guide

被引：122

作者：

Facer, GR ^{[1
]}

Notterman, DA

Sohn, LL

机构：

[1] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

APPLIED PHYSICS LETTERS | 2001年 / 78卷 / 07期

关键词：

D O I：

10.1063/1.1347020

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We report developing coplanar waveguide devices which can perform dielectric spectroscopy on biological samples within a microfluidic channel or well. Since coupling to the fluid sample is capacitive, no surface functionalization or chemical sample preparation are required. Data on cell suspensions and solutions of proteins and nucleic acids spanning the frequency range from 40 Hz to 26.5 GHz are presented. Low-frequency data are well explained using a simple dispersion model. At microwave frequencies, the devices yield reproducible and distinguishable spectral responses for hemoglobin solution and live E. coli. (C) 2001 American Institute of Physics.

引用

页码：996 / 998

页数：3

共 22 条

[1] Real-time monitoring of yeast cell division by dielectric spectroscopy [J].