Genetic counselling for schizophrenia in the era of molecular genetics

被引:37
作者
Hodgkinson, KA
Murphy, J
O'Neill, S
Brzustowicz, L
Bassett, AS
机构
[1] Ctr Addict & Mental Hlth, Queen St Div, Schizophrenia Res Program, Genet Sect, Toronto, ON M6J 1H4, Canada
[2] Mem Univ Newfoundland, Dept Genet, St John, NF, Canada
[3] Univ Med & Dent New Jersey, Dept Genet, Piscataway, NJ 08854 USA
[4] Univ Med & Dent New Jersey, Dept Psychiat, Piscataway, NJ 08854 USA
[5] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
来源
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 2001年 / 46卷 / 02期
关键词
genetic counselling; schizophrenia; 22q deletion syndrome; psychiatric genetics;
D O I
10.1177/070674370104600202
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: To review the role of genetic counselling for individuals with psychiatric illnesses. Method: Using schizophrenia as an example and including updated information about a genetic subtype (22q deletion syndrome), we discuss the value of the genetic counselling process in psychiatry, with support from the literature and our clinical experience. Results: Genetic counselling, the process through which knowledge about the genetics of illnesses is shared, provides information on the inheritance of illnesses and their recurrence risks; addresses the concerns of patients, their families, and their health care providers: and supports patients and their families dealing with these illnesses. For comprehensive medical management, this service should be available to all individuals with schizophrenia and their families. Conclusions: New findings in the genetics of psychiatric illness may have important clinical implications for patients and their families.
引用
收藏
页码:123 / 130
页数:8
相关论文
共 102 条
[1]  
ANDREASEN NC, 1986, ARCH GEN PSYCHIAT, V43, P421
[2]  
[Anonymous], 1982, SCHIZOPHRENIA EPIGEN
[3]  
[Anonymous], BIOL BASIS SCHIZOPHR
[4]  
Bassett A, 1998, CAN J PSYCHIAT, V43, p25S
[5]   22q11 deletion syndrome: A genetic subtype of schizophrenia [J].
Bassett, AS ;
Chow, EWC .
BIOLOGICAL PSYCHIATRY, 1999, 46 (07) :882-891
[6]  
Bassett AS, 1999, SCHIZOPHR RES, V36, P87
[7]   Genetic insights into schizophrenia [J].
Bassett, AS ;
Chow, EWC ;
Waterworth, DM ;
Brzustowicz, L .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2001, 46 (02) :131-137
[8]   PSYCHIATRIC-DISORDERS IN THE FAMILIES OF PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER [J].
BELLODI, L ;
SCIUTO, G ;
DIAFERIA, G ;
RONCHI, P ;
SMERALDI, E .
PSYCHIATRY RESEARCH, 1992, 42 (02) :111-120
[9]  
BENJAMIN CM, 1994, AM J HUM GENET, V55, P606
[10]  
BLACK DW, 1992, ARCH GEN PSYCHIAT, V49, P362