Interleukin-2 promotes the motility of dendritic cells and their accumulation in lung and skin

被引:25
作者
Kradin, RL
Xia, WJ
Pike, M
Byers, HR
Pinto, C
机构
[1] MASSACHUSETTS GEN HOSP, PULMONARY & CRIT CARE UNIT, BOSTON, MA 02114 USA
[2] MASSACHUSETTS GEN HOSP, ARTHRITIS UNIT, BOSTON, MA 02114 USA
[3] MASSACHUSETTS GEN HOSP, DERMATOPATHOL UNIT, BOSTON, MA 02114 USA
关键词
dendritic cells; interleukin-2; motility;
D O I
10.1159/000164033
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Dendritic cells (DC) play a critical role as antigen-presenting cells in vivo. It has previously been shown that DC accumulate in the lung in response to parenteral injections of IFN-gamma. In the current paper, we report that rat DC express the interleukin-2 receptor (IL-2R) alpha-chain (OX-39) and display enhanced motility in response to IL-2 in Boyden chamber and video time-lapse microscopy assays. Increased motility was specifically inhibited by pretreating DC with OX-39 (anti-IL-2R) but not OX-22 (anti-CD45RC), an isotype-matched murine monoclonal antibody. The intratracheal injection of IL-2 increased the number of OX-6+ dendritic cells located around pulmonary venules and in the lung interstitium. When IL-2 was injected into the footpad of the rat. DC were increased around dermal venules at 24 h. This effect was blocked by the parenteral injection of anti-OX-39. We conclude that IL-2 is a potent enhancer of DC motility and may cooperate with other T helper(h)-1 proinflammatory cytokines in attracting DC to sites of inflammation.
引用
收藏
页码:180 / 186
页数:7
相关论文
共 21 条
  • [1] DENDRITIC CELLS INITIATE A 2-STAGE MECHANISM FOR LYMPHOCYTE-T PROLIFERATION
    AUSTYN, JM
    STEINMAN, RM
    WEINSTEIN, DE
    GRANELLIPIPERNO, A
    PALLADINO, MA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 157 (04) : 1101 - 1115
  • [2] BYERS HR, 1991, AM J PATHOL, V139, P423
  • [3] LYMPHOKINE-ACTIVATED KILLER CELL PHENOMENON - LYSIS OF NATURAL KILLER-RESISTANT FRESH SOLID TUMOR-CELLS BY INTERLEUKIN 2-ACTIVATED AUTOLOGOUS HUMAN PERIPHERAL-BLOOD LYMPHOCYTES
    GRIMM, EA
    MAZUMDER, A
    ZHANG, HZ
    ROSENBERG, SA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (06) : 1823 - 1841
  • [4] ACCESSORY CELLS OF THE LUNG .1. INTERFERON-GAMMA INCREASES IA+ DENDRITIC CELLS IN THE LUNG WITHOUT AUGMENTING THEIR ACCESSORY ACTIVITIES
    KRADIN, RL
    MCCARTHY, KM
    XIA, WJ
    LAZARUS, D
    SCHNEEBERGER, EE
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1991, 4 (03) : 210 - 218
  • [5] USUAL INTERSTITIAL PNEUMONITIS IS A T-CELL ALVEOLITIS
    KRADIN, RL
    DIVERTIE, MB
    COLVIN, RB
    RAMIREZ, J
    RYU, J
    CARPENTER, HA
    BHAN, AK
    [J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1986, 40 (02): : 224 - 235
  • [6] LOTZE MT, 1985, J IMMUNOL, V135, P2865
  • [7] MacLean JA, 1996, AM J PATHOL, V148, P657
  • [8] ONTOGENY OF IA+ ACCESSORY CELLS IN FETAL AND NEWBORN RAT LUNG
    MCCARTHY, KM
    GONG, JL
    TELFORD, JR
    SCHNEEBERGER, EE
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1992, 6 (03) : 349 - 356
  • [9] INDUCTION OF CIRCULATING TUMOR NECROSIS FACTOR (TNF-ALPHA) AS THE MECHANISM FOR THE FEBRILE RESPONSE TO INTERLEUKIN-2 (IL-2) IN CANCER-PATIENTS
    MIER, JW
    VACHINO, G
    VANDERMEER, JWM
    NUMEROF, RP
    ADAMS, S
    CANNON, JG
    BERNHEIM, HA
    ATKINS, MB
    PARKINSON, DR
    DINARELLO, CA
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 1988, 8 (06) : 426 - 436
  • [10] SELECTIVE INVITRO GROWTH OF T-LYMPHOCYTES FROM NORMAL HUMAN BONE MARROWS
    MORGAN, DA
    RUSCETTI, FW
    GALLO, R
    [J]. SCIENCE, 1976, 193 (4257) : 1007 - 1008