The effect of catalyst loading and donor ligands in the Mn(III) salen catalysed chiral epoxidation of chromenes: Synthesis of BRL 55834.

被引：24

作者：

Bell, D ^{[1
]}

Davies, MR ^{[1
]}

Finney, FJL ^{[1
]}

Geen, GR ^{[1
]}

Kincey, PM ^{[1
]}

Mann, IS ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AW,ESSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 22期

关键词：

D O I：

10.1016/0040-4039(96)00683-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the absence of a donor ligand both the reaction rate and product e.e. of the manganese (III) salen catalysed epoxidation of 2,2-dimethyl-6-pentafluoroethylchromene were dependent on the catalyst loading. Isoquinoline N-oxide was the most effective donor ligand, affording highly efficient epoxidations with catalyst loadings of 0.1-0.4 mol%. These findings allowed the realisation of a concise, inexpensive synthesis of BRL 55834. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3895 / 3898

页数：4

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