Location of cholic acid sequestered by core-shell nanoparticles using REDOR NMR

被引：26

作者：

Kao, HM ^{[1
]}

O'Connor, RD ^{[1
]}

Mehta, AK ^{[1
]}

Huang, HY ^{[1
]}

Poliks, B ^{[1
]}

Wooley, KL ^{[1
]}

Schaefer, J ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

MACROMOLECULES | 2001年 / 34卷 / 03期

关键词：

D O I：

10.1021/ma001429d

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Solid-state C-13{F-19} rotational-echo double-resonance (REDOR) NMR was used to locate [24-C-13]cholic acid that had been absorbed by nanoparticles with a core-shell morphology. The nanoparticles were composed of poly(4-fluorostyrene)-block-poly(acrylic acid) copolymers in which 15% of the poly(acrylic acid) shell functionality had been cross-linked with 2,2'-(ethylenedioxy)bis(ethylamine). The REDOR data were consistent with no cholic acid in the core, approximately 28% located at or near the core-shell interface, and the remaining 72% of the cholic acid farther than 25 Angstrom from the interface.

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页码：544 / 546

页数：3

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