Functional MRI of lateral occipitotemporal cortex during pursuit and motion perception

被引:87
作者
Barton, JJS
Simpson, T
Kiriakopoulos, E
Stewart, C
Crawley, A
Guthrie, B
Wood, M
Mikulis, D
机构
[1] UNIV TORONTO, DIV NEUROL, TORONTO, ON, CANADA
[2] UNIV TORONTO, PLAYFAIR NEUROSCI INST, TORONTO, ON, CANADA
[3] UNIV TORONTO, DEPT MED IMAGING, TORONTO, ON, CANADA
[4] MCMASTER UNIV, FAC MED, HAMILTON, ON, CANADA
[5] UNIV WATERLOO, SCH OPTOMETRY, WATERLOO, ON N2L 3G1, CANADA
关键词
D O I
10.1002/ana.410400308
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We performed functional imaging with a conventional 1.5-T magnetic resonance scanner in 9 normal subjects. We used a gradient-echo technique to examine changes in signal between periods when subjects viewed a stationary black-and-white grating, a moving grating, and when they followed a moving spot. We located image pixels with significant differences between the viewing conditions. In 7 subjects, these occurred in the lateral occipitotemporal cortex, a region previously identified as a putative human homologue of the motion-sensitive middle temporal area (MT, or V5) of monkeys. Signal intensity was greater during pursuit of the moving dot than during viewing of the moving grating with the eyes still, despite the fact that the moving grating generated more retinal image motion. In contrast, signal intensity in striate cortex was least during pursuit of the moving dot. These findings suggest that the lateral occipitotemporal cortex has extraretinal signals during pursuit. Such signals may include attentional input, corollary eye movement information, or even a pursuit command. Extraretinal signals suggest that the lateral occipitotemporal cortex may contain a human homologue not only of MT but also of other components of the monkey V5 complex, such as the medial superior temporal area.
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收藏
页码:387 / 398
页数:12
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