A sex-ratio meiotic drive system in Drosophila simulans.: II:: An X-linked distorter

被引：133

作者：

Tao, Yun ^{[1
,2
]}

Araripe, Luciana ^{[1
]}

Kingan, Sarah B. ^{[1
]}

Ke, Yeyan ^{[1
]}

Xiao, Hailian ^{[2
]}

Hartl, Daniel L. ^{[1
]}

机构：

[1] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA

[2] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

来源：

PLOS BIOLOGY | 2007年 / 5卷 / 11期

关键词：

D O I：

10.1371/journal.pbio.0050293

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The evolution of heteromorphic sex chromosomes creates a genetic condition favoring the invasion of sex-ratio meiotic drive elements, resulting in the biased transmission of one sex chromosome over the other, in violation of Mendel's first law. The molecular mechanisms of sex-ratio meiotic drive may therefore help us to understand the evolutionary forces shaping the meiotic behavior of the sex chromosomes. Here we characterize a sex-ratio distorter on the X chromosome (Dox) in Drosophila simulans by genetic and molecular means. Intriguingly, Dox has very limited coding capacity. It evolved from another X-linked gene, which also evolved de nova. Through retrotransposition, Dox also gave rise to an autosomal suppressor, not much yang (Nmy). An RNA interference mechanism seems to be involved in the suppression of the Dox distorter by the Nmy suppressor. Double mutant males of the genotype dox; nmy are normal for both sex-ratio and spermatogenesis. We postulate that recurrent bouts of sex-ratio meiotic drive and its subsequent suppression might underlie several common features observed in the heterogametic sex, including meiotic sex chromosome inactivation and achiasmy.

引用

页码：2576 / 2588

页数：13

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