Losartan corrects abnormal frequency response of renal vasculature in congestive heart failure

被引:11
作者
DiBona, GF
Sawin, LL
机构
[1] Univ Iowa, Coll Med, Dept Internal Med & Physiol & Biophys, Iowa City, IA 52242 USA
[2] Vet Adm Med Ctr, Iowa City, IA 52242 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2003年 / 285卷 / 05期
关键词
renal sympathetic nerves; renal blood flow; angiotensin AT(1) receptors;
D O I
10.1152/ajpheart.00364.2003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In congestive heart failure, renal blood flow is decreased and renal vascular resistance is increased in a setting of increased activity of both the sympathetic nervous and renin-angiotensin systems. The renal vasoconstrictor response to renal nerve stimulation is enhanced. This is associated with an abnormality in the low-pass filter function of the renal vasculature wherein higher frequencies ( greater than or equal to 0.01 Hz) within renal sympathetic nerve activity are not normally attenuated and are passed into the renal blood flow signal. This study tested the hypothesis that excess angiotensin II action mediates the abnormal frequency response characteristics of the renal vasculature in congestive heart failure. In anesthetized rats, the renal vasoconstrictor response to graded frequency renal nerve stimulation was significantly greater in congestive heart failure than in control rats. Losartan attenuated the renal vasoconstrictor response to a significantly greater degree in congestive heart failure than in control rats. In control rats, the frequency response of the renal vasculature was that of a first order ( - 20 dB/frequency decade) low-pass filter with a corner frequency ( - 3 dB, 30% attenuation) of 0.002 Hz and 97% attenuation ( - 30 dB) at greater than or equal to0.1 Hz. In congestive heart failure rats, attenuation did not exceed 45% ( - 5 dB) over the frequency range of 0.001 - 0.6 Hz. The frequency response of the renal vasculature was not affected by losartan treatment in control rats but was completely restored to normal by losartan treatment in congestive heart failure rats. The enhanced renal vasoconstrictor response to renal nerve stimulation and the associated abnormality in the frequency response characteristics of the renal vasculature seen in congestive heart failure are mediated by the action of angiotensin II on renal angiotensin II AT(1) receptors.
引用
收藏
页码:H1857 / H1863
页数:7
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