Nuclear migration, nucleokinesis and lissencephaly

被引:136
作者
Morris, NR [1 ]
Efimov, VP [1 ]
Xiang, X [1 ]
机构
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Newark, NJ 07103 USA
关键词
D O I
10.1016/S0962-8924(98)01389-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During the past 20 years, biologists have become used to finding that proteins first identified in simple, genetically manipulable eukaryotic organisms are conserved in higher eukaryotes. This article draws attention to the similarity between NUDF protein, which is required for nuclear migration in the filamentous fungus Aspergillus nidulans, and a mammalian homologue, LIS1, whose malfunction causes lissencephaly, a neuronal migration disease. The authors suggest that there might be an underlying similarity of mechanism between nuclear migration in the fungus and neuronal migration in the brain.
引用
收藏
页码:467 / 470
页数:4
相关论文
共 40 条
  • [1] PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells
    Adachi, T
    Aoki, J
    Manya, H
    Asou, H
    Arai, H
    Inoue, K
    [J]. NEUROSCIENCE LETTERS, 1997, 235 (03) : 133 - 136
  • [2] Bhattacharyya A, 1997, J NEUROSCI, V17, P7007
  • [3] DIRECT OBSERVATION INVITRO OF HOW NEUROBLASTS MIGRATE - MEDULLA AND COCHLEOVESTIBULAR GANGLION OF THE CHICK-EMBRYO
    BOOK, KJ
    HOWARD, R
    MOREST, DK
    [J]. EXPERIMENTAL NEUROLOGY, 1991, 111 (02) : 228 - 243
  • [4] The spleen protein-tyrosine kinase TPK-IIB is highly similar to the catalytic domain of p72(syk)
    Brunati, AM
    James, P
    Guerra, B
    Ruzzene, M
    DonellaDeana, A
    Pinna, LA
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 240 (02): : 400 - 407
  • [5] Genetic interactions among cytoplasmic dynein, dynactin, and nuclear distribution mutants of Neurospora crassa
    Bruno, KS
    Tinsley, JH
    Minke, PF
    Plamann, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (10) : 4775 - 4780
  • [6] Characterization of DnudC, the Drosophila homolog of an Aspergillus gene that functions in nuclear motility
    Cunniff, J
    Chiu, YH
    Morris, NR
    Warrior, R
    [J]. MECHANISMS OF DEVELOPMENT, 1997, 66 (1-2) : 55 - 68
  • [7] D'Arcangelo G, 1998, BIOESSAYS, V20, P235, DOI 10.1002/(SICI)1521-1878(199803)20:3&lt
  • [8] 235::AID-BIES7&gt
  • [9] 3.0.CO
  • [10] 2-Q