Nuclear migration, nucleokinesis and lissencephaly

被引:136
作者
Morris, NR [1 ]
Efimov, VP [1 ]
Xiang, X [1 ]
机构
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Newark, NJ 07103 USA
关键词
D O I
10.1016/S0962-8924(98)01389-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During the past 20 years, biologists have become used to finding that proteins first identified in simple, genetically manipulable eukaryotic organisms are conserved in higher eukaryotes. This article draws attention to the similarity between NUDF protein, which is required for nuclear migration in the filamentous fungus Aspergillus nidulans, and a mammalian homologue, LIS1, whose malfunction causes lissencephaly, a neuronal migration disease. The authors suggest that there might be an underlying similarity of mechanism between nuclear migration in the fungus and neuronal migration in the brain.
引用
收藏
页码:467 / 470
页数:4
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