Post-Epidemic Eosinophilia-Myalgia Syndrome Associated With L-Tryptophan

被引：44

作者：

Allen, Jeffrey A.

Peterson, Alicia

Sufit, Robert

Hinchcliff, Monique E.

Mahoney, J. Matthew ^{[2
]}

Wood, Tammara A. ^{[2
]}

Miller, Frederick W. ^{[3
]}

Whitfield, Michael L. ^{[2
]}

Varga, John ^{[1
]}

机构：

[1] Northwestern Univ, Div Rheumatol, Feinberg Sch Med, Chicago, IL 60612 USA

[2] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Hanover, NH 03756 USA

[3] NIEHS, NIH, Bethesda, MD USA

来源：

ARTHRITIS AND RHEUMATISM | 2011年 / 63卷 / 11期

关键词：

SCLERODERMA; INGESTION; CONTAMINANTS; EXPRESSION; FASCIITIS;

D O I：

10.1002/art.30514

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eosinophilia-myalgia syndrome (EMS) is characterized by subacute onset of myalgias and peripheral eosinophilia, followed by chronic neuropathy and skin induration. An epidemic of EMS in 1989 was linked to consumption of L-tryptophan that had originated from a single source. Following the ban by the Food and Drug Administration (FDA) on the sale of L-tryptophan, the incidence of EMS declined rapidly. Moreover, no new cases have been described since the FDA ban was lifted in 2005. We report the clinical, histopathologic, and immunogenetic features of a new case of L-tryptophan-associated EMS, along with evidence of activated transforming growth factor beta and interleukin-4 signaling in the lesional skin.

引用

页码：3633 / 3639

页数：7

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