Lessons from interleukin-deficient mice: the interleukin-1 system

被引：13

作者：

Fantuzzi, G ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Denver, CO 80262 USA

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 2001年 / 173卷 / 01期

关键词：

arthritis; cytokines; endotoxin; fever; inflammation; interleukin-1; interleukin-18; transgenic mice;

D O I：

10.1046/j.1365-201X.2001.00879.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The study of cytokine-deficient mice has provided important information for a better understanding of inflammatory processes. In this report, the characterization of mice deficient for various components of the interleukin (IL)-1 system is reviewed. Results obtained by studying mice deficient for IL-1 alpha, IL-1 beta, IL-1 receptor antagonist, IL-1 receptor type I, IL-1 receptor accessory protein, IL-1 receptor-associated kinase, and the IL-1 beta -converting enzyme caspase-1 are summarized. Because some of the components of the IL-1 system are shared with IL-18, similarities between IL-1 beta and IL-18 are also discussed.

引用

收藏

页码：5 / 9

页数：5

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