Delivery systems for DNA-binding drugs as gene expression modulators

被引：6

作者：

Cortesi, R

Nastruzzi, C

机构：

[1] Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy

[2] Dipartimento Chim & Tecnol Farm, I-06100 Perugia, Italy

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 17期

关键词：

D O I：

10.1016/S1359-6446(01)01893-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite the large number of publications describing the synthesis and physicocharacterization of the binding between drugs and DNA, relatively few examine drug delivery systems (DDSs) for these molecules. The aim to find DDSs for DNA-binding drugs (DBDs) was prompted mainly to reduce the toxicity and/or enhance the tumor specificity of systemically administered drugs. With this in mind, we have reviewed the biological effects of some DBDs that are currently used as antitumor drugs and describe a brief selection of DDSs currently in clinical trials or on the market.

引用

页码：893 / 904

页数：12

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