Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer

被引：57

作者：

Al-Khami, Amir A. ^{[1
,2
]}

Rodriguez, Paulo C. ^{[3
]}

Ochoa, Augusto C. ^{[1
,4
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Stanley S Scott Canc Ctr, New Orleans, LA USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Genet, New Orleans, LA USA

[3] Georgia Regents Univ, Ctr Canc, Augusta, GA USA

[4] Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, New Orleans, LA USA

来源：

ONCOIMMUNOLOGY | 2016年 / 5卷 / 08期

关键词：

Cancer; Immunometabolism; MDSC;

D O I：

10.1080/2162402X.2016.1200771

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

MDSC undergo metabolic reprogramming in the tumor resulting in an increased fatty acid beta oxidation that supports their immunosuppressive functions. Fatty acid oxidation inhibitors, used to treat coronary disease, significantly delayed tumor growth and had a significantly increased antitumor effect when combined with adoptive cell therapy or low dose chemotherapy.

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