Development of a low-metal adhesive tape to detect and localize metals in or on the stratum corneum at parts per million levels

被引：4

作者：

Cullander, C ^{[1
]}

Grant, PG

Bench, G

机构：

[1] Univ Calif San Francisco, Sch Pharm, San Francisco, CA 94143 USA

[2] Lawrence Livermore Natl Lab, Hlth & Ecol Assessment Div, San Francisco, CA USA

来源：

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY | 2001年 / 14卷

关键词：

tape-stripping; skin; exposure assessment; stratum corneum; particle-induced X-ray emission;

D O I：

10.1159/000056390

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Tape-stripping is a well-established method for sampling the stratum corneum (SC). We have developed a tape with low-metal content suitable for use with particle-induced Xray emission (PIXE), an analytical technique based on X-ray spectrometry. PIXE analysis of tape-stripped samples of SC is a reliable and minimally invasive means of identifying and quantifying metals present at parts per million levels. Assay feasibility and reproducibility was demonstrated using human volunteers. This new tape-strip technique has potential applications in exposure and decontamination assessment, diagnosis of metal dermatitis, forensics, and in environmental research. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：46 / 51

页数：6