The pathophysiological mechanisms underlying freezing of gait in Parkinson's Disease

被引：79

作者：

Shine, J. M. ^{[1
]}

Naismith, S. L. ^{[1
]}

Lewis, S. J. G. ^{[1
]}

机构：

[1] Univ Sydney, Brain & Mind Res Inst, Parkinsons Dis Res Clin, Camperdown, NSW 2050, Australia

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2011年 / 18卷 / 09期

关键词：

Freezing of gait; Parkinson's Disease; Pathophysiological mechanism; ANTICIPATORY POSTURAL ADJUSTMENTS; BILATERAL COORDINATION; WALKING; SUBTYPES; LOCOMOTION; MOVEMENT; IMPACT; FALLS; FOG; PD;

D O I：

10.1016/j.jocn.2011.02.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Freezing of gait is a paroxysmal phenomenon most commonly found in patients with advanced Parkinson's Disease. The pathophysiological mechanisms underlying this behaviour remain uncertain despite a well-characterised phenotype. Freezing behaviour extends beyond gait to affecting speech and upper limb function, suggesting that there is likely to be a universal mechanism underlying the phenomenon. This paper identifies the essential features required for a comprehensive model of freezing and evaluates a number of hypotheses that seek to explain the phenomenon. It appears likely that the pathophysiology of freezing involves context-dependant dysfunction across multiple levels of the neurological system, including cortical, subcortical and brainstem regions. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

引用

页码：1154 / 1157

页数：4

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