Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

被引：142

作者：

Parker, Matthew W.

Xu, Ping

Li, Xiaobo

Vander Kooi, Craig W. ^{[1
]}

机构：

[1] Univ Kentucky, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 14期

基金：

美国国家卫生研究院;

关键词：

EXON 7-ENCODED DOMAIN; HEPARIN-BINDING; RECEPTOR ACTIVATION; CELL MIGRATION; TUMOR-CELLS; SEMAPHORIN; VEGF(165); COMPLEX; GROWTH-FACTOR-165; TRANSDUCTION;

D O I：

10.1074/jbc.M111.331140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Neuropilin is an essential cell surface receptor for VEGF-A in angiogenesis. Results: VEGF-A(164) uniquely physically engages neuropilin using two distinct regions. Conclusion: These data establish the structural basis for selective VEGF-A splice form binding to neuropilin. Significance: Understanding VEGF receptor binding will advance therapeutic targeting of pathological angiogenesis.

引用

收藏

页码：11082 / 11089

页数：8

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