A crucial role of MafA as a novel therapeutic target for diabetes

被引：107

作者：

Kaneto, H ^{[1
]}

Matsuoka, T ^{[1
]}

Nakatani, Y ^{[1
]}

Miyatsuka, T ^{[1
]}

Matsuhisa, M ^{[1
]}

Hori, M ^{[1
]}

Yamasaki, Y ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2005年 / 280卷 / 15期

关键词：

D O I：

10.1074/jbc.M412013200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MafA, a recently isolated pancreatic beta-cell-specific transcription factor, is a potent activator of insulin gene transcription. In this study, we show that MafA overexpression, together with PDX-1 ( pancreatic and duodenal homeobox factor-1) and NeuroD, markedly increases insulin gene expression in the liver. Consequently, substantial amounts of insulin protein were induced by such combination. Furthermore, in streptozotocin-induced diabetic mice, MafA overexpression in the liver, together with PDX-1 and NeuroD, dramatically ameliorated glucose tolerance, while combination of PDX-1 and NeuroD was much less effective. These results suggest a crucial role of MafA as a novel therapeutic target for diabetes.

引用

页码：15047 / 15052

页数：6

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