Distinct death mechanisms in Drosophila development

被引:59
作者
Ryoo, Hyung Don [1 ]
Baehrecke, Eric H. [2 ]
机构
[1] NYU, Dept Cell Biol, New York, NY 10016 USA
[2] Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01605 USA
基金
美国国家卫生研究院;
关键词
PROGRAMMED CELL-DEATH; MUCOLIPIDOSIS TYPE-IV; APOPTOTIC CELLS; STEROID REGULATION; TEAD/TEF FAMILY; AUTOPHAGY; PROTEIN; PHAGOCYTOSIS; DRAPER; DEGRADATION;
D O I
10.1016/j.ceb.2010.08.022
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Apoptosis and autophagic cell death occur during Drosophila development, and recent advances in their mechanisms have been made. As in other organisms, apoptosis is executed by caspases. In living cells, caspases are kept in check through a combination of IAP-binding and proteolytic inhibition. Once a cell commits to apoptosis, phagocytes recognize them through the immuno-receptor-like proteins Draper and Simu, and initiate corpse engulfment. Drosophila research has significantly contributed to the idea that autophagy is required for certain forms of cell death, and that caspase function in autophagic cell death depends on cell context. Surprisingly, the cell corpse engulfment receptor Draper also functions in autophagic cell death. These advances facilitate our understanding of the cell death mechanisms in development and disease.
引用
收藏
页码:889 / 895
页数:7
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