Silent, but deadly - eliminating reservoirs of latent HIV

被引：5

作者：

Kay, MS ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84132 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2003年 / 21卷 / 10期

关键词：

D O I：

10.1016/j.tibtech.2003.08.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

HIV treatment with highly active anti-retroviral therapy cannot eliminate latent reservoirs of HIV. In a recent paper, Root and Hamer describe a novel targeting mechanism for killing HIV-infected cells. They show that 5-helix (a gp4l-binding protein) fused to a Pseudomonas exotoxin fragment can selectively kill cells displaying envelope proteins on their surface from a broad range of HIV strains.

引用

页码：420 / 423

页数：4

共 11 条

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