Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions

被引:541
作者
Piccinni, MP
Beloni, L
Livi, C
Maggi, E
Scarselli, G
Romagnani, S
机构
[1] Univ Florence, Inst Internal Med Immonoallergol, I-50134 Florence, Italy
[2] Univ Florence, Inst Obstet & Gynecol, I-50134 Florence, Italy
关键词
D O I
10.1038/2006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Leukemia inhibitory factor is essential for embryo implantation, and a shift from type 1 T-helper to type 2 T-helper response at the fetal-maternal interface may contribute to successful pregnancy. We show that LIF production is associated with type 2 T-helper cells, is upregulated by IL-4 and progesterone and is downregulated by IL-12 IFN-gamma and IFN-alpha. We also show a decreased production of LIF, IL-4 and IL-10 by decidual T cells of women with unexplained recurrent abortions in comparison with that of women with normal gestation. The defective production of LIF and/or type 2 T-helper cytokines may contribute to the development of unexplained recurrent abortions.
引用
收藏
页码:1020 / 1024
页数:5
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