Microrheology of red blood cell membranes using dynamic scattering microscopy

被引：51

作者：

Amin, M. Shahrooz ^{[1
]}

Park, YoungKeun ^{[1
]}

Lue, Niyom ^{[1
]}

Dasari, Ramachandra R. ^{[1
]}

Badizadegan, Kamran ^{[1
,2
,3
]}

Feld, Michael S. ^{[1
]}

Popescu, Gabriel ^{[1
,4
]}

机构：

[1] MIT, George R Harrison Spect Lab, Cambridge, MA 02139 USA

[2] Massachusetts Gen Hosp, Harvard Med Sch, Dept Pathol, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Harvard Med Sch, Dept Hlth Sci & Technol, Boston, MA 02114 USA

[4] Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Elect & Comp Engn, Quantitat Light Imaging Lab, Urbana, IL 61801 USA

来源：

OPTICS EXPRESS | 2007年 / 15卷 / 25期

关键词：

D O I：

10.1364/OE.15.017001

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We employ a novel optical technique, dynamic scattering microscopy (DSM), to extract the frequency dependence of the viscoelastic modulus associated with the red blood cell membrane. This approach applies the principle of dynamic light scattering to micro beads attached to the red blood cell membrane in thermal fluctuation. This allows for high-throughput characterization of a large number of cells simultaneously, which represents a significant advantage over current methods. The results in terms of the effective loss and storage moduli indicate the generic behavior of a viscoelastic material, characterized by power laws with exponents between 0 and 1. (c) 2007 Optical Society of America.

引用

页码：17001 / 17009

页数：9

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