The development and function of lung-resident macrophages and dendritic cells

被引:398
作者
Kopf, Manfred [1 ]
Schneider, Christoph [1 ]
Nobs, Samuel P. [1 ]
机构
[1] Swiss Fed Inst Technol, Inst Mol Hlth Sci, Dept Biol, Zurich, Switzerland
基金
瑞士国家科学基金会;
关键词
REGULATORY T-CELLS; COLONY-STIMULATING FACTOR; HUMAN ALVEOLAR MACROPHAGES; INNATE IMMUNE-RESPONSE; INFLUENZA-VIRUS; GM-CSF; IN-VIVO; STREPTOCOCCUS-PNEUMONIAE; AIRWAY INFLAMMATION; TISSUE MACROPHAGES;
D O I
10.1038/ni.3052
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Gas exchange is the vital function of the lungs. It occurs in the alveoli, where oxygen and carbon dioxide diffuse across the alveolar epithelium and the capillary endothelium surrounding the alveoli, separated only by a fused basement membrane 0.2-0.5 mu m in thickness. This tenuous barrier is exposed to dangerous or innocuous particles, toxins, allergens and infectious agents inhaled with the air or carried in the blood. The lung immune system has evolved to ward off pathogens and restrain inflammation-mediated damage to maintain gas exchange. Lung-resident macrophages and dendritic cells are located in close proximity to the epithelial surface of the respiratory system and the capillaries to sample and examine the air-borne and blood-borne material. In communication with alveolar epithelial cells, they set the threshold and the quality of the immune response.
引用
收藏
页码:36 / 44
页数:9
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