Statin-mediated inhibition of Rho - Only to get more NO?

被引：15

作者：

Brandes, RP ^{[1
]}

机构：

[1] Univ Frankfurt, Fachbereich Med, Inst Kardiovaskulaire Physiol, D-60596 Frankfurt, Germany

来源：

CIRCULATION RESEARCH | 2005年 / 96卷 / 09期

关键词：

statins; nitric oxide; endothelium; GTPases; hypertension;

D O I：

10.1161/01.RES.0000168040.70096.2a

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：927 / 929

页数：3

共 19 条

[11] Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle [J].

Sauzeau, V ;

Le Jeune, H ;

Cario-Toumaniantz, C ;

Smolenski, A ;

Lohmann, SM ;

Bertoglio, J ;

Chardin, P ;

Pacaud, P ;

Loirand, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (28) :21722-21729

[12] Signaling from Ras to Rac and beyond: not just a matter of GEFs [J].

Scita, G ;

Tenca, P ;

Frittoli, E ;

Tocchetti, A ;

Innocenti, M ;

Giardina, G ;

Di Fiore, PP .

EMBO JOURNAL, 2000, 19 (11) :2393-2398

[13] Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth [J].

Searles, CD ;

Ide, L ;

Davis, ME ;

Cai, H ;

Weber, M .

CIRCULATION RESEARCH, 2004, 95 (05) :488-495

[14] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery [J].

Shiga, N ;

Hirano, K ;

Hirano, M ;

Nishimura, J ;

Nawata, H ;

Kanaide, H .

CIRCULATION RESEARCH, 2005, 96 (09) :1014-1021

[15] New roads leading to Ca2+ sensitization [J].

Somlyo, AV .

CIRCULATION RESEARCH, 2002, 91 (02) :83-84

[16] Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase [J].

Takemoto, M ;

Sun, JX ;

Hiroki, J ;

Shimokawa, H ;

Liao, JK .

CIRCULATION, 2002, 106 (01) :57-62

[17] Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension [J].

Uehata, M ;

Ishizaki, T ;

Satoh, H ;

Ono, T ;

Kawahara, T ;

Morishita, T ;

Tamakawa, H ;

Yamagami, K ;

Inui, J ;

Maekawa, M ;

Narumiya, S .

NATURE, 1997, 389 (6654) :990-994

[18] Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation [J].

Wagner, AH ;

Köhler, T ;

Rückschloss, U ;

Just, I ;

Hecker, M .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (01) :61-69

[19] Endothelium-dependent effects of statins [J].

Wolfrum, S ;

Jensen, KS ;

Liao, JK .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (05) :729-736

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