Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy

被引：60

作者：

Griffin, John M.

Martin, Dave R.

Brown, Steven P. ^{[1
]}

机构：

[1] Univ Warwick, Dept Phys, Coventry CV4 7AL, W Midlands, England

[2] AstraZeneca R&D Charnwood, Loughborough LE11 5RH, Leics, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 42期

基金：

英国工程与自然科学研究理事会;

关键词：

analytical methods; drug design; NMR spectroscopy; polymorphism;

D O I：

10.1002/anie.200702582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation. Such a high-resolution spectrum constitutes a new analytical tool that should be routinely adopted in the characterization of pharmaceuticals. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：8036 / 8038

页数：3

相关论文

共 21 条

[1] Multinuclear NMR investigations of the oxygen, water, and hydroxyl environments in sodium hexaniobate [J].

Alam, TM ;

Nyman, M ;

Cherry, BR ;

Segall, JM ;

Lybarger, LE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (17) :5610-5620

[2] Ritonavir: An extraordinary example of conformational polymorphism [J].

Bauer, J ;

Spanton, S ;

Henry, R ;

Quick, J ;

Dziki, W ;

Porter, W ;

Morris, J .

PHARMACEUTICAL RESEARCH, 2001, 18 (06) :859-866

[3] Solid-state NMR spectroscopy in pharmaceutical research and analysis [J].

Berendt, Robert T. ;

Sperger, Diana M. ;

Isbester, Paul K. ;

Munson, Eric J. .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2006, 25 (10) :977-984

[4]

BERNSTEIN J, 2002, POLYM MOL CRYSTALS

[5] Probing proton-proton proximities in the solid state:: High-resolution two-dimensional 1H-1H double-quantum CRAMPS NMR spectroscopy [J].

Brown, SP ;

Lesage, A ;

Elena, B ;

Emsley, L .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (41) :13230-13231

[6]

Brown SP, 2001, ANGEW CHEM INT EDIT, V40, P717, DOI 10.1002/1521-3773(20010216)40:4<717::AID-ANIE7170>3.0.CO

[7]

2-X

[8] Advanced solid-state NMR methods for the elucidation of structure and dynamics of molecular, macromolecular, and supramolecular systems [J].

Brown, SP ;

Spiess, HW .

CHEMICAL REVIEWS, 2001, 101 (12) :4125-4155

[9] An investigation of the hydrogen-bonding structure in bilirubin by 1H double-quantum magic-angle spinning solid-state NMR spectroscopy [J].

Brown, SP ;

Zhu, XX ;

Saalwächter, K ;

Spiess, HW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (18) :4275-4285

[10] Probing proton-proton proximities in the solid state [J].

Brown, Steven P. .

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 2007, 50 (04) :199-251