Laparoscopic-assisted cecectomy is associated with decreased formation of postoperative pulmonary metastases compared with open cecectomy in a murine model

被引:35
作者
Carter, JJ [1 ]
Feingold, DL [1 ]
Kirman, I [1 ]
Oh, A [1 ]
Wildbrett, P [1 ]
Asi, Z [1 ]
Fowler, R [1 ]
Huang, E [1 ]
Whelan, RL [1 ]
机构
[1] Columbia Univ Coll Phys & Surg, Dept Surg, Laparoscop Physiol Lab, New York, NY USA
关键词
D O I
10.1067/S0039-6060(03)00136-3
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background. It was shown in a marine model that sham laparotomy is associated with a higher incidence of postoperative lung metastases when compared with results seen after. carbon dioxide pneumoperitoneum. Using the same tumor model, the present study was undertaken to determine if the addition of bowel resection to the operative procedure would impact the results. Methods. Sixty mice underwent anesthesia alone (anesthesia control [AC]), laparoscopic-assisted cecectomy (LC), or open cecectomy (OC). After surgery, all animals received tail vein injections of 105 TA3-Ha tumor cells. On postoperative day 14, the lungs and trachea were excised en bloc and processed, and surface lung metastases were counted and recorded by a blinded observer. Results. The mean number of surface lung metastases in the AC, LC, and OC groups was 30.9, 76.3, and 134.5, respectively. Significantly more metastases were documented after OC (P < .001) and LC (P < .05) than after anesthesia alone. Mice in the LC group had significantly fewer lung metastases (43% less) than mice in the OC group (P < . 01). Conclusions. OC was associated with significantly more lung metastases than either LC or AC. Surgery-related immune suppression or trophic tumor cell stimulation occurring after surgery may contribute to this phenomenon.
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页码:432 / 436
页数:5
相关论文
共 25 条
  • [1] A murine model of laparoscopic-assisted intervention
    Allendorf, JDF
    Bessler, M
    Whelan, RL
    [J]. SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES, 1997, 11 (06): : 622 - 624
  • [2] Increased tumor establishment and growth after open vs laparoscopic surgery in mice may be related to differences in postoperative T-cell function
    Allendorf, JDF
    Bessler, M
    Horvath, KD
    Marvin, MR
    Laird, DA
    Whelan, RL
    [J]. SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES, 1999, 13 (03): : 233 - 235
  • [3] Better preservation of immune function after laparoscopic-assisted vs open bowel resection in a murine model
    Allendorf, JDF
    Bessler, M
    Whelan, RL
    Trokel, M
    Laird, DA
    Terry, MB
    Treat, MR
    [J]. DISEASES OF THE COLON & RECTUM, 1996, 39 (10) : S67 - S72
  • [4] Increased tumor establishment and growth after open vs laparoscopic bowel resection in mice
    Allendorf, JDF
    Bessler, M
    Horvath, KD
    Marvin, MR
    Laird, DA
    Whelan, RL
    [J]. SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES, 1998, 12 (08): : 1035 - 1038
  • [5] ALLENDORF JDF, 1995, ARCH SURG-CHICAGO, V130, P649
  • [6] Bouvy ND, 1997, BRIT J SURG, V84, P358
  • [7] Da Costa ML, 1998, BRIT J SURG, V85, P1439
  • [8] The effect of laparotomy and laparoscopy on the establishment of spontaneous tumor metastases
    Da Costa, ML
    Redmond, HP
    Bouchier-Hayes, DJ
    [J]. SURGERY, 1998, 124 (03) : 516 - 525
  • [9] Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma
    Decker, D
    Schondorf, M
    Bidlingmaier, F
    Hirner, A
    vonRuecker, AA
    [J]. SURGERY, 1996, 119 (03) : 316 - 325
  • [10] EGGERMONT AMM, 1988, CANCER DETECT PREV, V12, P421