Thiouroninm-thymine conjugate as a new carrier for selective transport of 5′-AMP

被引：42

作者：

Yeo, WS ^{[1
]}

Hong, JI ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 151742, South Korea

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(98)00612-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Extraction and transport behaviors of the new 5'-AMP receptors which have thiouronium group and which have both thiouronium and thymine group were investigated. As expected, the sequence of transport rate was 1 > 3 similar to 2 > 4. 1 showed the best transport ability, since it has both concave bis(thiouronium) binding site which can chelate phospate anion and covalently linked bis(thymine) moiety which can interact with adenine in 5'-AMP by hydrogen bonding involving both Watson-Crick and Hoogsteen recognition patterns. The less transport ability of 2 and 4 was assumed to be the result of disadvantage in complexation process entropically and enthalpically. The control experiment clearly showed that selective base-pairing contributed to increased transport. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3769 / 3772

页数：4

共 25 条

[1] SYNTHETIC ANALOGS OF THE RISTOCETIN BINDING-SITE - NEUTRAL, MULTIDENTATE RECEPTORS FOR CARBOXYLATE RECOGNITION [J].