From nucleosome to chromosome: a dynamic organization of genetic information

被引：71

作者：

Fransz, Paul ^{[1
]}

de Jong, Hans ^{[2
]}

机构：

[1] Univ Amsterdam, Swammerdam Inst Life Sci, Nucl Org Grp, NL-1098 XH Amsterdam, Netherlands

[2] Wageningen Univ & Res Ctr, Genet Lab, Wageningen, Netherlands

来源：

PLANT JOURNAL | 2011年 / 66卷 / 01期

关键词：

chromosome; chromatine structure; nucleosome positioning; nucleus; heterochromatin; HISTONE VARIANT H2A.Z; 30-NM CHROMATIN FIBER; ARABIDOPSIS-THALIANA; DNA METHYLATION; INTERPHASE CHROMOSOMES; IN-VIVO; NUCLEAR ARCHITECTURE; INSITU HYBRIDIZATION; REGULATORY REGIONS; H4-K16; ACETYLATION;

D O I：

10.1111/j.1365-313X.2011.04526.x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

P>Gene activity is controlled at different levels of chromatin organization, which involve genomic sequences, nucleosome structure, chromatin folding and chromosome arrangement. These levels are interconnected and influence each other. At the basic level nucleosomes generally occlude the DNA sequence from interacting with DNA-binding proteins. Evidently, nucleosome positioning is a major factor in gene control and chromatin organization. Understanding the biological rules that govern the deposition and removal of the nucleosomes to and from the chromatin fiber is the key to understanding gene regulation and chromatin organization. In this review we describe and discuss the relationship between the different levels of chromatin organization in plants and animals.

引用

页码：4 / 17

页数：14

共 146 条

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