BTLA: a new inhibitory receptor with a B7-like ligand

被引：80

作者：

Carreno, BM ^{[1
]}

Collins, M ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Cambridge, MA 02140 USA

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 10期

关键词：

D O I：

10.1016/j.it.2003.08.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The B and T lymphocyte attenuator, BTLA, is a recently discovered Ig superfamily member. BTLA engagement results in downregulation of T-cell activation, and mice deficient in BTLA show increased incidence and severity of autoimmune disorders. A novel B7 family member, B7x (B7S1, B7-H4), has been proposed as the ligand for BTLA. A B7x-Ig fusion protein inhibits T-cell activation and interleukin-2 (IL-2) production. Thus, cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1) and BTLA comprise an expanding set of inhibitory receptors expressed on lymphocytes.

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页码：524 / 527

页数：4

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