PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

被引：379

作者：

Nishimura, H ^{[1
]}

Honjo, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 05期

关键词：

D O I：

10.1016/S1471-4906(01)01888-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The constitutive expression of PD-1 ligands (PD-L1 and PD-LP) on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.

引用

页码：265 / 268

页数：4

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