Early patterning of the C-elegans embryo

被引：139

作者：

Rose, LS ^{[1
]}

Kemphues, KJ

机构：

[1] Univ Calif Davis, Sect Mol & Cellular Biol, Davis, CA 95616 USA

[2] Cornell Univ, Genet & Dev Sect, Ithaca, NY 14853 USA

来源：

ANNUAL REVIEW OF GENETICS | 1998年 / 32卷

关键词：

asymmetric division; maternal-effect mutation; cell-cell signaling; spindle orientation;

D O I：

10.1146/annurev.genet.32.1.521

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Studies of about 20 maternally expressed genes are providing an understanding of mechanisms of patterning and cell-fate determination in the early Caenorhabditis elegans embryo. The analyses have revealed that fates of the early blastomeres are specified by a combination of intrinsically asymmetric cell divisions and two types of cell-cell interactions: inductions and polarizing interactions. In this review we summarize the current level of understanding of the molecular mechanisms underlying these processes in the specification of cell fates in the pregastrulation embryo.

引用

页码：521 / 545

页数：25