Regulatory T cells in stem cell transplantation: strategies and first clinical experiences

被引：128

作者：

Edinger, Matthias ^{[1
]}

Hoffmann, Petra ^{[1
]}

机构：

[1] Univ Hosp Regensburg, Dept Hematol & Oncol, D-93053 Regensburg, Germany

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 05期

关键词：

VERSUS-HOST-DISEASE; TRANSCRIPTION FACTOR FOXP3; BONE-MARROW-TRANSPLANTATION; IN-VITRO EXPANSION; DNA METHYLATION; LYMPHOPROLIFERATIVE DISORDER; EPIGENETIC CONTROL; CUTTING EDGE; EXPRESSION; RAPAMYCIN;

D O I：

10.1016/j.coi.2011.06.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adoptive transfer of donor-type CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) protects from graft-versus-host disease in murine bone marrow transplantation models. Results from first clinical trials exploring such strategies have recently been presented and seem to confirm the efficacy of Treg for the prevention of this severe complication after allogeneic stem cell transplantation. Further improvements in Treg isolation and in vitro expansion technologies will facilitate the broader exploration of Treg therapies, for example, for the treatment of ongoing graft-versus-host disease or the prevention of graft rejection after solid organ transplantation.

引用

页码：679 / 684

页数：6

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