Influence of electrostatic interactions and hydrogen bonding on the activity of cyclodextrin-based superoxide dismutase models

被引：8

作者：

Fragoso, A ^{[1
]}

Cao, R ^{[1
]}

Díaz, A ^{[1
]}

Sánchez, I ^{[1
]}

Sánchez, L ^{[1
]}

机构：

[1] Univ Havana, Fac Chem, Lab Bioinorgan Chem, Havana 10400, Cuba

来源：

SUPRAMOLECULAR CHEMISTRY | 2001年 / 13卷 / 05期

关键词：

cyclodextrin; dithiocarbamate; SOD-like activity; copper complex;

D O I：

10.1080/10610270108039795

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The influence of electrostatic interactions and hydrogen bonding between the substrate and the active site in superoxide dismutase (SOD) models based on Cu(II) complexes of cyclodextrin dithiocarbamates is studied. Polar and positively charged groups present in the structure of the complexes were found to increase its activity in 35-70%. Our studies reveal the importance of these two features in enhancing the activity of SOD model complexes.

引用

页码：619 / 625

页数：7

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