Preparation of resin-bound ketimines via transimination and its application in the synthesis of hydantoin libraries

被引：17

作者：

Lee, SH ^{[1
]}

Chung, SH ^{[1
]}

Lee, YS ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Chem Engn, Seoul 151742, South Korea

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(98)02147-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-H Ketimines were prepared from various ketones and ammonia using titanium tetrachloride and were used to form resin-bound ketimines via transimination. They were applied to the solid phase synthesis of hydantoins 1 with four substituent variations using two other building blocks (amino acids and isocyanates). The desired products were obtained with high purity in moderate to good yields in 5 steps. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9469 / 9472

页数：4

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