Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology

被引：31

作者：

Cheng Xiao-Rui ^{[1
,2
]}

Qi Chun-Hui ^{[1
]}

Wang Tong-Xing ^{[1
,2
]}

Zhou Wen-Xia ^{[1
,2
]}

Zhang Yong-Xiang ^{[1
,2
]}

机构：

[1] Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

[2] State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2019年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Liu-Wei-Di-Huang; Traditional Chinese medicine; Pharmacology; Phytochemistry; Pharmacokinetics; Toxicology; PERFORMANCE LIQUID-CHROMATOGRAPHY; PRONE; 8; STRAIN; CHINESE HERBAL FORMULA; AGE-RELATED EXPRESSION; TANG DERIVATIVES YMJD; YUKMIJIHWANG-TANG; DIHUANG DECOCTION; LW-AFC; GENE-EXPRESSION; MOUSE MODEL;

D O I：

10.1016/S1875-5364(19)30013-5

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases. Quality control and pharmacokinetic parameters of LW are mostly based on its major bioactive phytochemical constituents. We postulate that modulating or rebalancing the neuroendocrine immunomodulation network in the body is the underlying mechanism of the multiple pharmacological activities displayed by LW.

引用

页码：103 / 121

页数：19

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