A study of typhoid fever in five Asian countries: disease burden and implications for controls

被引：428

作者：

Ochiai, R. Leon ^{[1
]}

Acosta, Camilo J. ^{[1
]}

Danovaro-Holliday, M. Carolina ^{[1
]}

Baiqing, Dong ^{[2
]}

Lhattacharya, Sujit K. ^{[3
]}

Agtini, Magdarina D. ^{[4
]}

Bhutta, Zulfiqar A. ^{[5
]}

Canh, Do Gia ^{[6
]}

Ali, Mohammad ^{[1
]}

Shin, Seonghye ^{[1
]}

Wain, John ^{[7
]}

Page, Anne-Laure ^{[1
]}

Albert, M. John ^{[8
]}

Farrari, Jeremy ^{[9
]}

Abu-Elyazeed, Remon ^{[10
]}

Pang, Tikki ^{[11
]}

Galindo, Claudia M. ^{[1
]}

von Seidlein, Lorenz ^{[1
]}

Clemens, John D. ^{[1
]}

机构：

[1] Internat Vaccine Inst, Seoul 151818, South Korea

[2] Guangxi Ctr Dis Control & Prevent, Guangxi, Peoples R China

[3] Natl Inst Cholera & Enter Dis, Kolkata, India

[4] Natl Inst Hlth Res & Dev, Jakarta, Indonesia

[5] Aga Khan Univ, Dept Paediat, Karachi, Pakistan

[6] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam

[7] Wellcome Trust Sanger Inst, Cambridge, England

[8] Kuwait Univ, Fac Med, Dept Microbiol, Kuwait, Kuwait

[9] Univ Oxford, Clin Res Unit, Oxford, England

[10] USNAMRU 3, Enter Dis Res Program, Epidemiol Unit, Cairo, Egypt

[11] World Hlth Org, Geneva, Switzerland

来源：

BULLETIN OF THE WORLD HEALTH ORGANIZATION | 2008年 / 86卷 / 04期

关键词：

D O I：

10.2471/BLT.06.039818

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective To inform policy-makers about introduction of preventive interventions against typhoid, including vaccination. Methods A population-based prospective surveillance design was used. Study sites where typhoid was considered a problem by local authorities were established in China, India, Indonesia, Pakistan and Viet Nam. Standardized clinical, laboratory, and surveillance methods were used to investigate cases of fever of >= 3 days' duration for a one-year period. A total of 441 435 persons were under surveillance, 159 856 of whom were aged 5-15 years. Findings A total of 21 874 episodes of fever were detected. Salmonella typhi was isolated from 475 (2%) blood, cultures, 57% (273/475) of which were from 5-15 year-olds. The annual typhoid incidence (per 100 000 person years) among this age group varied from 24.2 and 29.3 in sites in Viet Nam and China, respectively, to 180.3 in the site in Indonesia; and to 412,9 and 493.5 in sites in Pakistan and India, respectively. Altogether, 23% (96/413) of isolates were multidrug resistant (chloramphenicol, ampicillin and trimethoprim-sulfamethoxazole). Conclusion The incidence of typhoid varied substantially between sites, being high in India and Pakistan, intermediate in Indonesia, and low in China and Viet Nam. These findings highlight the considerable, but geographically heterogeneous, burden of typhoid fever in endemic areas of Asia, and underscore the importance of evidence on disease burden in making policy decisions about interventions to control this disease.

引用

页码：260 / 268

页数：9