Tracking of oocyte dysmorphisms for ICSI patients may prove relevant to the outcome in subsequent patient cycles

被引:72
作者
Meriano, JS [1 ]
Alexis, J [1 ]
Visram-Zaver, S [1 ]
Cruz, M [1 ]
Casper, RF [1 ]
机构
[1] Univ Toronto, Dept Obstet & Gynecol, Div Reprod Sci, Toronto Ctr Adv Reprod Technol, Toronto, ON M5G 1Z5, Canada
关键词
cytoplasm; ICSI outcome; implantation rates; oocytes dysmorphisms; organelle clustering;
D O I
10.1093/humrep/16.10.2118
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: We determined whether oocyte dysmorphisms, especially repetition of specific dysmorphisms from cycle to cycle, had a prognostic impact on intracytoplasmic sperm injection (ICSI) outcome. METHODS: ICSI patients (n = 67) were grouped as follows: group 1 > 50% phenotypically dysmorphic oocytes per cohort (cytoplasmic and extra-cytoplasmic dysmorphisms) with no repetition of a specific dysmorphism from cycle one to cycle two (36 cycles and 274 oocytes); group 2 > 50% dysmorphic oocytes per cohort and repetition of the same dysmorphism from cycle one to cycle two (32 cycles and 313 oocytes); group 3 (control) < 30% dysmorphic oocytes (33 cycles and 378 oocytes). RESULTS: In group 2 (repetitive), 47% of oocytes were observed to have organelle clustering versus 20.5% in group I and 17.3% in group 3 (P < 0.001). There was no difference between the groups in fertilization rates, cleavage rates or embryo quality. Embryos derived from normal oocytes were transferred in each group (57, 33 and 72% respectively). The clinical pregnancy and implantation rates in group 2 (3.1 and 1.7% respectively) were lower (P < 0.01, P = 0.005) than both group 1 (28 and 15% respectively) and group 3 (45.5 and 26.5% respectively). CONCLUSIONS: The low implantation rate in group 2, even though 33% of transferred embryos were derived from morphologically normal oocytes, suggests that repetitive organelle clustering may be associated with an underlying adverse factor affecting the entire follicular cohort.
引用
收藏
页码:2118 / 2123
页数:6
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