Gastric stump cancer: What is the risk?

被引:66
作者
Safatle-Ribeiro, AV [1 ]
Ribeiro, U [1 ]
Reynolds, JC [1 ]
机构
[1] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA
关键词
partial gastrectomy; stump cancer; gastric remnant; peptic ulcer surgery;
D O I
10.1159/000016860
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Patients who have undergone partial gastric resections are at an increased risk for the development of cancer in the gastric remnant. The overall risk increases over time and is higher in patients with an initial diagnosis of gastric rather than duodenal ulcer, in men and following partial gastrectomy with Billroth II reconstruction. The site of tumor growth is predominantly in the anastomotic area, but may occur anywhere in the stump. Enterogastric reflux, achlorhydria, bacteria overgrowth, and Helicobacter pylori appear to be the major factors involved in the etiopathogenesis of the gastric stump cancer. Surveillance of these patients with endoscopy and multiple biopsies may provide the means to diagnose tumors at an early stage, but the cost-benefit ratio of surveillance requires further study. Despite the magnitude of alterations in gastric stump mucosa? unfortunately, at this time we do not have good predictors of patients who will develop a cancer.
引用
收藏
页码:159 / 168
页数:10
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