Characterization of small intestinal submucosa regenerated canine detrusor: Assessment of reinnervation, in vitro compliance and contractility

被引:136
作者
Kropp, BP
Sawyer, BD
Shannon, HE
Rippy, MK
Badylak, SF
Adams, MC
Keating, MA
Rink, RC
Thor, KB
机构
[1] INDIANA UNIV, SCH MED, RILEY CHILDRENS HOSP, DEPT UROL, INDIANAPOLIS, IN USA
[2] ELI LILLY & CO, DIV CNS GI GU RES, INDIANAPOLIS, IN 46285 USA
[3] PURDUE UNIV, WILLIAM A HILLENBRAND BIOMED ENGN CTR, W LAFAYETTE, IN 47907 USA
关键词
bladder; muscle; smooth; innervation; regeneration; biocompatible materials;
D O I
10.1016/S0022-5347(01)65761-6
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose: We characterized small intestinal submucosa regenerated canine bladde Materials and Methods: We subjected 15-month small intestinal submucosa regenerated canine bladder strips to in vitro muscle bath compliance, contractility testing and immunohistochemical staining. Results: Compliance studies demonstrated no significant difference between small intestinal submucosa regenerated and control bladders, which were 30-fold more compliant than native small intestinal submucosal graft material. Contractility studies demonstrated contractile responses and innervation similar to those of normal canine bladder. Afferent nerves were demonstrated through immunohistochemical techniques. Conclusions: These characteristics further support the regenerative capacity of small intestinal submucosa and its potential use as a bladder augmentation material.
引用
收藏
页码:599 / 607
页数:9
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