Do infectious agents play a role in dementia?

被引：42

作者：

Dobson, CB ^{[1
]}

Wozniak, MA ^{[1
]}

Itzhaki, RF ^{[1
]}

机构：

[1] Univ Manchester, Mol Neurobiol Lab, Dept Optometry & Neurosci, Manchester M60 1QD, Lancs, England

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 07期

关键词：

D O I：

10.1016/S0966-842X(03)00146-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number of people surviving to old age and concomitantly, the number affected by the diseases of old age, is increasing steadily. Alzheimer's disease (AD) affects one in five people aged over 80. The causes are unknown, but obviously, elucidation of the mechanisms of initiation and development of the disease is urgently required. This review describes studies on the possible role of infectious agents in dementia, particularly those on herpes simplex virus type 1, which, we discovered, resides latently in a high proportion of brains of the elderly and in combination with a certain genetic factor, is responsible for a high proportion of AD cases.

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页码：312 / 317

页数：6

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