Enhanced vulnerability to apoptotic cell death in sporadic Alzheimer's disease

被引：15

作者：

Eckert, A

Cotman, CW

Zerfass, R

Hennerici, M

Müller, WE

机构：

[1] Goethe Univ Frankfurt, Bioctr, Dept Pharmacol, D-60439 Frankfurt, Germany

[2] Heidelberg Univ, Cent Inst Mental Hlth, Dept Psychiat, Mannheim, Germany

[3] Heidelberg Univ, Klinikum Mannheim, Fac Med, Dept Neurol, Mannheim, Germany

[4] UCI, Inst Brain Aging & Dementia, Irvine, CA USA

来源：

NEUROREPORT | 1998年 / 9卷 / 11期

关键词：

Alzheimer's disease; apoptosis; lymphocytes; nucleosomes;

D O I：

10.1097/00001756-199808030-00003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ALL important neuropathological features like neurodegeneration and amyloid deposition occur similarly in familial and in sporadic Alzheimer's disease (AD) patients, suggesting a common pathogenetic mechanism. We investigated whether defective vulnerability to the induction of the apoptotic cell death pathway might be one of the underlying mechanisms leading to progressive cell death in sporadic AD. Our test could prove useful in supporting the diagnosis of AD and in predicting individuals predisposed to AD. NeuroReport 9: 2443-2446 (C) 1998 Rapid Science Ltd.

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收藏

页码：2443 / 2446

页数：4

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