Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis

被引：82

作者：

Borrell, S. ^{[1
,2
]}

Gagneux, S. ^{[1
,2
]}

机构：

[1] Swiss Trop & Publ Hlth Inst Swiss TPH, Dept Med Parasitol & Infect Biol, Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 06期

基金：

瑞士国家科学基金会; 美国国家卫生研究院;

关键词：

Antimicrobial; diversity; genotyping; lineage; microbe; mycobacteria; ANTIBIOTIC-RESISTANCE; ISONIAZID RESISTANCE; RIFAMPIN RESISTANCE; GENOMIC DELETIONS; FITNESS; COST; MUTATIONS; GENE; PHYLOGEOGRAPHY; ASSOCIATION;

D O I：

10.1111/j.1469-0691.2011.03556.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mycobacterium tuberculosis harbours little DNA sequence diversity compared with other bacteria. However, there is mounting evidence that strain-to-strain variation in this organism has been underestimated. We review our current understanding of the genetic diversity among M. tuberculosis clinical strains and discuss the relevance of this diversity for the ongoing global epidemics of drug-resistant tuberculosis. Based on findings in other bacteria, we propose that epistatic interactions between pre-existing differences in strain genetic background, acquired drug-resistance-conferring mutations and compensatory changes could play a role in the emergence and spread of drug-resistant M. tuberculosis.

引用

页码：815 / 820

页数：6

共 61 条

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